FORM GUIDE
United beat Real Betis 4-1 on Thursday evening, with goals from Marcus Rashford, Antony, Bruno Fernandes and Wout Weghorst helping provide the perfect response to Sunday’s setback at Anfield.
Despite Southampton’s lowly league position, the south-coast side remain just one point away from Premier League safety.
The Saints defeated Leicester City at St Mary’s last time out, thanks to Alcaraz’s goal, and visit Old Trafford looking to record back-to-back wins for the first time in the league this season.
Back in August, United edged Southampton 1-0 in the reverse fixture, courtesy of a sublime Bruno Fernandes volley.
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